研究業績

原著論文（95報）

2024

  1. H. Horiuchi, K. Nishikawa, N. Ishi, K. Kano, S. Shinada, N. Osawa, A. Horikoshi, T. Yoshihara, F. Sugawara, K. Sakaguchi, T. Okutsu, S. Katsura, I. Matsuo, M. Oshige
    A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-a-D-glucopyranose functions as an efficient photosensitizer for photodynamic therapy
    Photodiagn. Photodyn. Ther., 45, 103898, 2024.

2023

  1. N. Ieda, M. Sawada, R. Oguchi, M. Itoh, S. Hirakata, D. Saitoh, A. Nakao, M. Kawaguchi, K. Sawamoto, T. Yoshihara, Y. Mori, H. Nakagawa
    An optochemical oxygen scavenger enabling spatiotemporal control of hypoxia
    Angew. Chem. Int. Ed., 62, e202217585, 2023.
  2. K. Purevsuren, Y. Shibuta, S. Shiozaki, M. Tsunoda, K. Mizukami, S. Tobita, T. Yoshihara*
    Blue-emitting lipid droplet probes based on coumarin dye for multi-color imaging of living cells and fatty livers of mice
    J. Photochem. Photobiol. A: Chem., 438, 114562, 2023.
  3. K. Purevsuren, S. Shiozaki, K. Mizukami, S. Tobita, T. Yoshihara*
    In vivo imaging of lipid droplets and oxygen status in hepatic tissues of nonalcoholic fatty liver model mice using a lipophilic Ir(III) complex
    Anal. Chem., 95, 3729-3735, 2023.

2022

  1. A. Narazaki, R. Shimizu, T. Yoshihara, J. Kikuta, R. Sakaguchi, S. Tobita, Y. Mori, M. Ishii, K. Nishikawa
    Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy
    Sci. Rep., 12, 3497, 2022.
  2. T. Yoshihara*, N. Matsumura, T. Tamura, S. Shiozaki, S. Tobita
    Intracellular and intravascular oxygen sensing of pancreatic tissues based on phosphorescence lifetime imaging microscopy using lipophilic and hydrophilic iridium(III) complexes
    ACS Sens., 7, 545-554, 2022.
  3. K. Mizukami, T. Muraoka, S. Shiozaki, S. Tobita, T. Yoshihara*
    Near-infrared emitting Ir(III) complexes bearing a dipyrromethene ligand for oxygen imaging of deeper tissues in vivo
    Anal. Chem., 94, 2794-2802, 2022.
  4. Y. Naito, R. Moriguchi, C. Kitamura, T. Matsumoto, T. Yoshihara, T. Ishi‐i, Y. Nagata, H. Takeshita, K. Yoshizawa, Y. Shiota, K. Suzuki, S. Kato
    Augmented self‐association by electrostatic forces in thienopyrrole‐fused thiadiazoles that contain an ester instead of an ether linker
    Chem. Asian J., 17, e202101341, 2022.

2021

  1. C. Balachandran, K. Yokoi, K. Naito, J. Haribabu, Y. Tamura, M. U., K. Tsuchiya, T. Yoshihara, S. Tobita, S. Aoki
    Cyclometalated iridium(III) complex–cationic peptide hybrids trigger paraptosis in cancer cells via an intracellular Ca2+ overload from the endoplasmic reticulum and a decrease in mitochondrial membrane potential
    Molecules, 26, 7028, 2021.
  2. K. Nishikawa, S. Seno, T. Yoshihara, A. Narazaki, Y. Sugiura, R. Shimizu, J. Kikuta, R. Sakaguchi, N. Suzuki, N. Takeda, H. Semba, M. Yamamoto, D. Okuzaki, D. Motooka, Y. Kobayashi, M. Suematsu, H. Koseki, H. Matsuda, M. Yamamoto, S. Tobita, Y. Mori, M Ishii
    Osteoclasts adapt to physioxia perturbation through DNA demethylation
    EMBO Rep., 22, e53035, 2021.
  3. S. Kataoka, S. Suzuki, Y. Shiota, K. Yoshizawa, T. Matsumoto, M. S. Asano, T. Yoshihara, C. Kitamura, S. Kato
    S,​C,​C- and O,​C,​C-​Bridged triarylamines and their persistent radical cations
    J. Org. Chem., 86, 12559-12568, 2021.
  4. N. Tsuchida, T. Takagi, H. Takahashi, T. Yoshihara, S. Tobita, M. Sonoyama
    Membrane properties of amacrocyclic tetraether bisphosphatidylcholine lipid: Effect of a single membrane-spanning polymethylene cross-linkage between two head groups of ditetradecylphosphatidylcholine membrane
    Biochim. Biophys. Acta Biomembr., 1863, 183569, 2021.
  5. H. Takakura, Y. Goto, A. Kitamura, T. Yoshihara, S. Tobita, M. Kinjo, M. Ogawa
    Analysis of the triplet-state kinetics of a photosensitizer for photoimmunotherapy by fluorescence correlation spectroscopy
    J. Photochem. Photobiol. A: Chem., 408, 113094, 2021.
  6. M. Yasukagawa, A. Shimada, S. Shiozaki, S. Tobita, T. Yoshihara*
    Phosphorescent Ir(III) complexes conjugated with oligoarginine peptides serve as optical probes for in vivo microvascular imaging
    Sci. Rep., 11, 4733, 2021.
  7. T. Honda, Y. Hirakawa, K. Mizukami, T. Yoshihara, T. Tanaka, S. Tobita, M. Nangaku
    A distinctive distribution of hypoxia-​inducible factor-​1α in cultured renal tubular cells with hypoperfusion simulated by coverslip placement
    Physiol. Rep., 9, e14689, 2021.

2020

  1. K. Mizukami, A. Katano, S. Shiozaki, T. Yoshihara*, N. Goda, S. Tobita
    In vivo O2 imaging in hepatic tissues by phosphorescence lifetime imaging microscopy using Ir(III) complexes as intracellular probes
    Sci. Rep., 10, 21053, 2020.
  2. T. Ryo, M. Kamiya, A. Morozumi, Y. Miyazaki, H. Fujioka, A. Nanjo, R. Kojima, T. Komatsu, T. Ueno, K. Hanaoka, T. Yoshihara, S. Tobita, Y. Urano
    Design of spontaneously blinking fluorophore for live-cell super resolution imaging based on quantum-chemical calculations
    Chem. Commun., 56, 13173-13176, 2020.
  3. A. Morozumi, M. Kamiya, S. Uno, K. Umezawa, R. Kojima, T. Yoshihara, S. Tobita, Y. Urano
    Spontaneously blinking fluorophores based on nucleophilic addition/dissociation of intracellular glutathione for live-cell super-resolution imaging
    J. Am. Chem. Soc., 142, 9625-9633 2020.
  4. T. Yoshihara, R. Maruyama, S. Shiozaki, K. Yamamoto, S. Kato, Y. Nakamura, S. Tobita
    Visualization of lipid droplets in living cells and fatty livers of mice based on the fluorescence of π-extended coumarin using fluorescence lifetime imaging microscopy
    Anal. Chem., 92, 4996-5003 2020.
  5. S. Kato, T. Kijima, Y. Shiota, T. Abe, S. Kuwako, H. Miyauchi, N. Yoshikawa, K. Yamamoto, K. Yoshizawa, T. Yoshihara, S. Tobita, Y. Nakamura
    Chemical transformation of push-pull fluorenones: push-pull dibenzodicyanofulvenes as well as fluorenone- and dibenzodicyanofulvene-tetracyanobutadiene conjugates
    Org. Bio. Chem., 18, 4198-4209, 2020.
  6. S. Kato, T. Matsuoka, S. Suzuki, M. S. Asano, T. Yoshihara, S. Tobita, T. Matsumoto, C. Kitamura
    Synthesis, structures, and properties of neutral and radical cationic S,C,C-bridged triphenylamines
    Org. Lett., 22, 734-738, 2020.
  7. R. Hoshi, K. Suzuki, N. Hasebe, T. Yoshihara, S. Tobita
    Absolute quantum yield measurements of near-infrared emission with correction for solvent absorption
    Anal. Chem., 92 607-611, 2020.

2019

  1. M. Yasukagawa, K. Yamada, S. Tobita, T. Yoshihara*
    Ratiometric oxygen probes with a cell-penetrating peptide for imaging oxygen levels in living cells
    J. Photochem. Photobiol. A: Chem., 383, 111983, 2019.
  2. K. Sano, T. Kuribara, N. Ishii, A. Kuroiwa, T. Yoshihara, S. Tobita, K. Totani, I. Matsuo
    Fluorescence quenching‐based assay for measuring golgi endo‐α‐mannosidase
    Chem. Asian J., 14, 1965-1969 2019.
  3. N. Ieda, Y. Oka, T. Yoshihara, S. Tobita, T. Sasamori, M. Kawaguchi, H. Nakagawa
    Structure-efficiency relationship of photoinduced electron transfer-triggered nitric oxide releasers
    Sci. Rep., 9, 1430, 2019.

2018

  1. Y. Hirakawa, K. Mizukami, T. Yoshihara, I. Takahashi, K. Purevsuren, T. Honda, I. Mimura, T. Tanaka, S. Tobita, M. Nangaku
    Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia
    Kidney Int., 93, 1483-1489, 2018.
  2. H. Akiyama, I. Takahashi, Y. Shimoda, R. Mukai, T. Yoshihara, S. Tobita
    Ir(III) complex-based oxygen imaging of living cells and ocular fundus with a gated ICCD camera
    Photochem. Photobiol. Sci., 17, 846-853, 2018.

2017

  1. H. Horiuchi, A. Sakai, S. Akiyama, R. Ikeda, S. Ito, M. Furuya, Y. Gomibuchi, M. Ichikawa, T. Yoshihara, S. Tobita, T. Okutsu
    Extension of π-system of silylated porphyrin derivative for photodynamic therapy
    J. Photochem. Photobiol. A: Chem., 339, 19-24, 2017.
  2. T. Yoshihara*, Y. Hirakawa, M. Hosaka, M. Nangaku, S. Tobita
    Oxygen imaging of living cells and tissues using luminescent molecular probes
    J. Photochem. Photobiol. A: Photochem. Rev., 30, 71-95, 2017.
  3. M. Lukina, A. Orlova, M. Shirmanova, D. Shirokov, A. Pavlikov, A. Neubauer, H. Studier, W. Becker, E. Zagaynova, T. Yoshihara, S. Tobita, V. Shcheslavskiy
    Interrogation of metabolic and oxygen states of tumors with fiber-based luminescence lifetime spectroscopy
    Opt. Lett., 42, 731-734, 2017.

2016

  1. S. Kato, T. Kijima, Y. Shiota, T. Yoshihara, S. Tobita, K. Yoshizawa, Y. Nakamura
    Push-pull fluorenones and benzazulenequinones: regioselective [4+2] and [2+2] cycloadditions of benzopentalenequinone derivative and alkynes bearing an aniline moiety
    Tetrahedron Lett., 57, 4604-4607, 2016.
  2. H. Moritomo, A. Fujii, Y. Suzuki, T. Yoshihara, S. Tobita, J. Kawamata
    Biological oxygen sensing via two-photon absorption by an Ir(III) complex using a femtosecond fiber laser
    Jpn. J. Appl. Phys., 55, 92401, 2016.
  3. S. Tobita, T. Yoshihara
    Intracellular and in vivo oxygen sensing using phosphorescent iridium(III) complexes
    Curr. Opin. Chem. Biol., 33, 39-45, 2016.
  4. N. Hasebe, Y. Deguchi, S. Murayama, T. Yoshihara, H. Horiuchi, T. Okutsu, S. Tobita
    Phosphorescence quenching of neutral and cationic iridium(III) complexes by molecular oxygen and aromatic electron acceptors
    J. Photochem. Photobiol. A: Chem., 324, 134-144, 2016.
  5. H. Horiuchi, K. Terashima, A. Sakai, D. Suda, T. Yoshihara, A. Kobayashi, S. Tobita, T. Okutsu
    The effect of central metal on the photodynamic properties of silylated tetraphenylporphyrin derivative.
    J. Photochem. Photobiol. A: Chem., 321, 72-78, 2016.

2015

  1. Y. Hirakawa, T. Yoshihara, M. Kamiya, I. Mimura, D. Fujikura, T. Masuda, R. Kikuchi, I. Takahashi, Y. Urano, S. Tobita, M. Nangaku
    Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement
    Sci. Rep., 5, 17838, 2015.
  2. T. Yoshihara, S. Murayama, S. Tobita
    Ratiometric molecular probes based on dual emission of a blue fluorescent coumarin and a red phosphorescent cationic iridium(III) complex for intracellular oxygen sensing
    Sensors, 15, 13503-13521, 2015.
  3. T. Yoshihara, M. Hosaka, M. Terata, K. Ichikawa, S. Murayama, A. Tanaka, M. Mori, H. Itabashi, T. Takeuchi, S. Tobita
    Intracellular and in vivo oxygen sensing using phosphorescent Ir(III) complexes with a modified acetylacetonato ligand
    Anal. Chem., 87, 2710-2717, 2015.
  4. N. Hasebe, K. Suzuki, H. Horiuchi, H. Suzuki, T. Yoshihara, T. Okutsu, S. Tobita
    Absolute phosphorescence quantum yields of singlet molecular oxygen in solution determined using an integrating sphere instrument
    Anal. Chem., 87, 2360-2366, 2015.
  5. T. Yoshihara, S. Murayama, T. Masuda, T. Kikuchi, K. Yoshida, M. Hosaka, S. Tobita
    Mitochondria-​targeted oxygen probes based on cationic iridium complexes with a 5-amino-​1,10-​phenanthroline ligand
    J. Photochem. Photobiol. A: Chem., 299, 172-182, 2015.
  6. T. Ishi-i, I. Kitahara, S. Yamada, Y. Sanada, K. Sakurai, A. Tanaka, N. Hasebe, T. Yoshihara, S. Tobita
    Amphiphilic benzothiadiazole-triphenylamine-​based aggregates that emit red light in water
    Org. Biomol. Chem., 13, 1818-1828, 2015.
  7. S. Kato, T. Furuya, M. Nitani, N. Hasebe, Y. Ie, Y. Aso, T. Yoshihara, S. Tobita, Y. Nakamura
    A series of π-extended thiadiazoles fused with electron-donating heteroaromatic moieties: Synthesis, properties, and polymorphic crystals
    Chem. Eur. J., 21, 3115-3128, 2015.

2014

  1. Y. Kataoka, H. Fujita, Y. Kasahara, T. Yoshihara, S. Tobita, M. Kuwahara
    Minimal thioflavin T modifications improve visual discrimination of guanine-quadruplex topologies and alter compound-​induced topological structures
    Anal. Chem., 86, 12078-12084, 2014.
  2. S. Uno, K. Kamiya, T. Yoshihara, K. Sugawara, K. Okabe, M. C. Tarhan, H. Fujita, T. Funatsu, Y. Okada, S. Tobita, Y. Urano
    A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging
    Nat. Chem., 8, 681-689, 2014.
  3. S. Prior, A. Kim, T. Yoshihara, S. Tobita, T. Takeuchi, M. Higuchi
    Mitochondrial respiratory function induces endogenous hypoxia
    PLoS One, 9, e88911, 2014.
  4. S. Katoh, S. Shimizu, A. Kobayashi, T. Yoshihara, S. Tobita, Y. Nakamura
    Systematic structure-​property investigations on a series of alternating carbazole-​thiophene oligomers
    J. Org. Chem., 79, 618-629, 2014.

2013

  1. S. Katoh, N. Takahashi, H. Tanaka, A. Kobayashi, T. Yoshihara, S. Tobita, T. Yamanobe, H. Uehara, Y. Nakamura
    Tetraalkoxyphenanthrene-fused dehydroannulenes: synthesis, self-assembly, and electronic, optical, and electrochemical properties
    Chem. Eur. J., 19, 12138-12151, 2013.
  2. T. Murase, T. Yoshihara, K. Yamada, S. Tobita
    Fluorescent peptides labeled with environment-sensitive 7-aminocoumarins and their interactions with lipid bilayer membranes and living cells
    Bull. Chem. Soc. Jpn., 86, 510-519, 2013.

2012

  1. S. Katoh H. Noguchi, A. Kobayashi, T. Yoshihara, S. Tobita, Y. Nakamura
    Bicarbazoles: systematic structure-property investigation on a series of conjugated carbazole dimers
    J. Org. Chem., 77, 9120-9133, 2012.
  2. S. Katoh, T. Furuya, A. Kobayashi, M. Nitani, Y. Ie, Y. Aso, T. Yoshihara, S. Tobita, Y. Nakamura
    p-Extended thiadiazoles fused with thienopyrrole or indole moieties: synthesis, structures, and properties
    J. Org. Chem., 77, 7595-7606, 2012.
  3. A. Kobayashi, K. Takehira, T. Yoshihara, S. Uchiyama, S. Tobita
    Remarkable fluorescence enhancement of benzo[g]chromen-2-ones induced by hydrogen-bonding interactions with protic solvents.
    Photochem. Photobiol. Sci., 11, 1368-1376, 2012.
  4. S. Uchiyama, K. Kimura, C. Gota, K. Okabe, K. Kawamoto, N. Inada, T. Yoshihara, S. Tobita
    Environment-sensitive fluorophores with benzothiadiazole and benzoselenadiazole structures as candidate components of a fluorescent polymeric thermometer
    Chem. Eur. J., 18, 9552-9563, 2012.
  5. T. Yoshihara, Y. Yamaguchi, S. Tobita
    Ratiometric molecular sensor for monitoring oxygen levels in living cells
    Angew. Chem. Int. Ed., 51, 4148-4151, 2012.
  6. T. Murase, T. Yoshihara, S. Tobita
    Mitochondria-specific oxygen probe based on iridium complexes bearing triphenylphosphonium cation
    Chem. Lett., 41, 262-263, 2012.

2011

  1. M. Matsubayashi, C. Kajimura, Y. Kubo, T. Yoshihara, S. Tobita
    Control of photophysical properties of 1,8-naphthalimides by electron-withdrawing substituents introduced into N-alkyl side chains
    Bull. Chem. Soc. Jpn., 84, 520-525, 2011.

2010

  1. M. Matsubayashi, C. Kajimura, H. Shiratori, Y. Kubo, T. Yoshihara, S. Tobita
    Kinetic analysis for the effect of intramolecular hydrogen bonding on photophysical properties of N-hydroxyalkyl-1,8-naphthalimides
    Bull. Chem. Soc. Jpn., 83, 1067-1073, 2010.
  2. S. Zhang, M. Hosaka, T. Yoshihara, K. Negishi, Y. Ida, S. Tobita, T. Takeuchi
    Phosphorescent light-emitting iridium complexes serve as a hypoxia-sensing probe for tumor imaging in living animals
    Cancer Res., 70, 4490-4498, 2010.
  3. A. Kobayashi, K. Suzuki, T. Yoshihara, S. Tobita
    Absolute measurements of photoluminescence quantum yields of 1-halonaphthalenes in 77 K rigid solution using an integrating sphere instrument
    Chem. Lett., 39, 282-283, 2010.

2009-1996 (37報)

  1. K. Suzuki, A. Kobayashi, S. Kaneko, K. Takehira, T. Yoshihara, H. Ishida, Y. Shiina, S. Oishi, S. Tobita
    Reevaluation of absolute luminescence quantum yields of standard solutions using a spectrometer with an integrating sphere and a back-thinned CCD detector
    Phys. Chem. Chem. Phys., 11, 9850-9860, 2009.
  2. H. Shimizu, Y. Kakinoya, K. Takehira, T. Yoshihara, S. Tobita, Y. Nakamura, J. Nishimura
    Synthesis and photophysical properties of N-arylcarbazolophanes
    Bull. Chem. Soc. Jpn., 82, 860-869, 2009.
  3. H. Shimizu, A. Kobayashi, S. Itoi, T. Yoshihara, S. Tobita, Y. Nakamura, J. Nishimura
    Substituent effects on photophysical properties of N-thienylcarbazoles
    Heterocycles, 78, 1265-1269, 2009.
  4. S. Kaneko, T. Yoshihara, S. Tobita
    The rate of excited-state proton transfer to solvent from trifluoromethylphenols in water
    Chem. Lett., 38, 312-313, 2009.
  5. A. Endo, K. Suzuki, T. Yoshihara, S. Tobita, M. Yahiro, C. Adachi
    Measurement of photoluminesence efficiency of Ir(III) phenylpyridine derivatives in solution and solid-state films
    Chem. Phys. Lett., 460, 155-157, 2008.
  6. C. Gota, S. Uchiyama, T. Yoshihara, S. Tobita, T. Ohwada
    Temperature-dependent fluorescence lifetime of a fluorescent polymetric thermometer poly(N-isopropylacrylamide), labeled by polarity and hydrogen bonding sensitive 4-sulfamoyl-7-aminobenzofurazan
    J. Phys. Chem. B, 112, 2829-2836, 2008.
  7. T. Konno, M. E. El-Khouly, Y. Nakamura, K. Kinoshita, Y. Araki, O. Ito, T. Yoshihara, S. Tobita, J. Nishimura
    Photoinduced intramolecular electron transfer of carbazole trimer-[60]fullerene studied by laser flash photolysis techniques
    J. Phys. Chem. C, 112, 1244-1249, 2008.
  8. H. Nakanotani, S. Akiyama, D. Ohnishi, M. Moriwake, M. Yahiro, T. Yoshihara, S. Tobita, C. Adachi
    Extremely low-threshold amplified spontaneous emission of 9,9’-spirobifluorene derivatives and electroluminescence from field-effect transistor structure
    Adv. Funct. Mater., 17, 2328-2335, 2007.
  9. T. Yoshihara, Y. Tamaki, A. Furube, M. Murai, K. Hara, R. Katoh
    Effect of pH on absorption spectra of photogenerated holes in nanocrystalline TiO2 films
    Chem. Phys. Lett., 438, 268-273, 2007.
  10. Y. Nakamura, T. Konno, S. Watanabe, M. Suzuki, T. Yoshihara, S. Tobita, J. Nishimura
    Synthesis and photophysical properties of [60]fullerene adducts carrying oligocarbazole dendrons
    Chem. Lett., 36, 264-265, 2007.
  11. S. Uchiyama, K. Takehira, T. Yoshihara, S. Tobita, T. Ohwada
    Environment-Sensitive Fluorophore Emitting in Protic Environments
    Org. Lett., 8, 5869-5872, 2006.
  12. S. I. Druzhinin, V. A. Galievsky, T. Yoshihara, K. A. Zachariasse
    Intramolecular charge transfer and dielectric solvent relaxation in n-propyl cyanide. N-Phenylpyrrole and 4-dimethylamino-4’-cyanostilbene
    J. Phys. Chem. A, 110, 12760-12768, 2006.
  13. J. Oshima, T. Yoshihara, S. Tobita
    Water-induced fluorescence quenching of mono- and dicyanoanilines
    Chem. Phys. Lett., 423, 306-311, 2006.
  14. J. Oshima, H. Tsujimoto, T. Yoshihara, K. Yamada, R. Katakai, S. Tobita
    Photophysical properties of 3-[2-cyano-4-(dimethylamino)phenyl]alanine: A highly fluorescent and environment-sensitive amino acid with small molecular size
    Chem. Lett., 35, 620-621, 2006.
  15. J. Oshima, S. Shiobara, H. Naoumi, S. Kaneko, T. Yoshihara, A. K. Mishra, S. Tobita
    Extreme fluorescence sensitivity of some aniline derivatives to aqueous and nonaqueous environments: mechanistic study and its implication as a fluorescent probe
    J. Phys. Chem. A, 110, 4629-4637, 2006.
  16. T. Ishi-i, H. Tashiro, R. Kuwahara, S. Mataka, T. Yoshihara, S. Tobita
    An efficient energy transfer found in triphenylene/hexaazatriphenylene system with electric complimentarity and structural similarity
    Chem. Lett., 35, 158-159, 2006.
  17. J. Nishimura, T. Funaki, N. Saito, S. Inokuma, Y. Nakamura, S. Tajima, T. Yoshihara, S. Tobita
    The exo-outstretching effect governing the exclusive stereoselectivity of the intramolecular [2+2] photocycloaddition of vinylarenes
    Helv. Chim. Acta, 88, 1226-1239, 2005.
  18. H. Shimada, A. Nakamura, T. Yoshihara, S. Tobita
    Intramolecular and intermolecular hydrogen-bonding effects on photophysical properties of 2’-aminoacetophenone and its derivatives in solution
    Photochem. Photobiol. Sci., 4, 367-375, 2005.
  19. S. Inokuma, H. Ide, T. Yonekura, T. Funaki, S. Kondo, S. Shiobara, T. Yoshihara, S. Tobita, J. Nishimura
    Synthesis and complexing properties of [2.n](2,6)pyridinocrownophanes
    J. Org. Chem., 70, 1698-1703, 2005.
  20. T. Yoshihara, S. I. Druzhinin, A. Demeter, N. Kocher, D. Stalke, K. A. Zachariasse
    Kinetics of intramolecular charge transfer with N-phenylpyrrole in alkyl cyanides
    J. Phys. Chem. A, 109, 1497-1509, 2005.
  21. K. Hara, T. Sato, R. Katoh, A. Furube, T. Yoshihara, M. Murai, M. Kurashige, S. Ito, A. Shinpo, S. Suga, H. Arakawa
    Novel conjugated organic dyes for efficient dye-sensitized solar cells
    Adv. Funct. Mater., 15, 246-252, 2005.
  22. A. Furube, R. Katoh, T. Yoshihara, K. Hara, S. Murata, H. Arakawa, M. Tachiya
    Ultrafast direct and indirect electron-injection processes in a photoexcited dye-sensitized nanocrystalline zinc oxide film: The importance of exciplex intermediates at the surface
    J. Phys. Chem. B, 108, 12583-12592, 2004.
  23. T. Yoshihara, M. Murai, Y. Tamaki, A. Furube, R. Katoh
    Trace analysis by transient absorption spectroscopy: estimation of the solubility of C60 in polar solvents
    Chem. Phys. Lett., 394, 161-164, 2004.
  24. R. Katoh, A. Furube, Y. Tamaki, T. Yoshihara, M. Murai, K. Hara, S. Murata, H. Arakawa, M. Tachiya
    Microscopic imaging of the efficiency of electron injection from excited sensitizer dye into nanocrystalline ZnO film
    J. Photochem. Photobiol. A: Chem., 166, 69-74, 2004.
  25. T. Yoshihara, S. I. Druzhinin, K. A. Zachariasse
    Fast intramolecular charge transfer with a planar rigidized electron donor/acceptor molecule
    J. Am. Chem. Soc., 126, 8535-8539, 2004.
  26. R. Katoh, A. Furube, T. Yoshihara, K. Hara, G. Fujihashi, S. Takano, S. Murata, H. Arakawa, M. Tachiya
    Efficiencies of electron injection from excited N3 dye into nanocrystalline semiconductor (ZrO2, TiO2, ZnO, Nb2O5, SnO2, In2O3) films
    J. Phys. Chem. B, 108, 4818-4822, 2004.
  27. M. Yamaji, T. Yoshihara, T. Tachikawa, S. Tero-Kubota, S. Tobita, H. Shizuka, B. Marciniak
    A new-type photoreaction of a carbonyl compound part 1. Photoinduced w-bond dissociation in p-mercaptomethylbenzophenone studied by time-resolved EPR technique, steady-state and laser flash photolyses in solution
    J. Photochem. Photobiol. A: Chem., 162, 513-520, 2004.
  28. T. Yoshihara, R. Katoh, A. Furube, Y. Tamaki, M. Murai, K. Hara, S. Murata, H. Arakawa, M. Tachiya
    Identification of reactive species in photoexcited nanocrystalline TiO2 films by wide-wavelength-range (400-2500 nm) transient absorption spectroscopy
    J. Phys. Chem. B, 108, 3817-3823, 2004.
  29. T. Yoshihara, R. Katoh, A. Furube, M. Murai, Y. Tamaki, K. Hara, S. Murata, H. Arakawa, M. Tachiya
    Quantitative estimation of the efficiency of electron injection from excited sensitizer dye into nanocrystalline ZnO film
    J. Phys. Chem. B, 108, 2643-2647, 2004.
  30. S. I. Druzhinin, A. Demeter, V. A. Galievsky, T. Yoshihara, K. A. Zachariasse
    Thermally activated internal conversion with 4-(dimethylamino)benzonitrile, 4-(methylamino)benzonitrile, and 4-aminobenzonitrile in alkane solvents. No correction with intramolecular charge transfer
    J. Phys. Chem. A, 107, 8075-8085, 2003.
  31. T. Yoshihara, V. A. Galievsky, S. I. Druzhinin, S. Saha, K. A. Zachariasse
    Singlet excited sate dipole moments of dual fluorescent N-phenylpyrroles and 4-(dimethylamino)benzonitrile from solvatochromic and thermochromic spectral shifts
    Photochem. Photobiol. Sci., 2, 342-353, 2003.
  32. K. A. Zachariasse, T. Yoshihara, S. I. Druzhinin
    Picosecond and nanosecond fluorescence decays of 4-(dimethylamino)phenylacetylene in comparison with those of 4-(dimethylamino)benzonitrile. No evidence for intramolecular charge transfer and a nonfluorescing intramolecular charge-transfer state
    J. Phys. Chem. A, 106, 6325-6333, 2002.
  33. T. Yoshihara, H. Shimada, H. Shizuka S. Tobita
    Internal conversion of o-aminoacetophenone in solution
    Phys. Chem. Chem. Phys., 3, 4972-4978, 2001.
  34. T. Yoshihara, M. Yamaji, T. Itoh, J. Nishimura, H. Shizuka, S. Tobita
    Photochemistry of 1,4-anthraquinone studied by steady-state and laser-flash photolysis
    J. Photochem. Photobiol. A: Chem., 140, 7-13, 2001.
  35. S. Tobita, R. Kamiyama, K. Takehira, T. Yoshihara, S. Yotoriyama, H. Shizuka
    Radiationless processes of N,N-dimethylaniline derivatives in solution. Time-resolved optoacoustic studies
    Anal. Sci., 17, s50-s52, 2001.
  36. T. Yoshihara, M. Yamaji, T. Itoh, H. Shizuka, T. Shimokage, S. Tero-Kubota
    Hydrogen atom transfer and electron transfer reactions in the triplet p,p* state of 1,4-anthraquinone studied by CIDEP techniques and laser flash photolysis
    Phys. Chem. Chem. Phys., 2, 993-1000, 2000.
  37. T. Yoshihara, M. Yamaji, H. Shizuka
    Laser photolysis studies on hydrogen atom abstraction by triplet benzophenone from hydroxyanilinium ions
    Chem. Phys. Lett., 261, 431-436, 1996.

総説・解説

  1. 吉原利忠、りん光寿命顕微分光法による組織内酸素分圧イメージング、YAKUGAKU ZASSHI、144巻、pp. 275-283、2024.
  2. 吉原利忠、りん光寿命測定に基づく細胞・組織内酸素分圧、光化学、53巻、pp. 58-65、2022.
  3. 水上輝市、吉原利忠、りん光寿命法による細胞・組織内酸素イメージング、細胞、54巻、pp. 368-371、2022.
  4. 吉原利忠、蛍光性脂質滴プローブを用いた細胞および組織内脂質滴のライブイメージング、バイオインダストリー、38巻、pp. 74-81、2021.
  5. 吉原利忠、Ir(III)錯体のりん光寿命計測による細胞内酸素分圧測定法の開発、生物物理、61巻、pp. 298-302、2021．
  6. 吉原利忠、飛田成史、りん光プローブによる酸素環境の感知、実験医学、38巻、pp. 1458-1463、2020.
  7. 吉原利忠、水上輝市、塩崎秀一、平川陽亮、南学正臣、飛田成史、りん光寿命計測に基づく組織内酸素分圧イメージング、JSMI Report、12巻、pp. 3-8、2019.
  8. 本田智子，平川陽亮，吉原利忠，飛田成史，南学正臣、りん光性分子プローブによる生体内酸素環境のイメージング、細胞、50巻、pp. 186-189、2018.
  9. 吉原利忠、飛田成史、りん光寿命計測による細胞・組織内酸素濃度定量、ファルマシア、53巻、pp. 220-224、2017.
  10. 飛田成史、吉原利忠、光学的方法による細胞・組織内酸素濃度計測、細胞、45巻、pp. 592-595、2013.
  11. 吉原利忠、飛田成史、イリジウム錯体のりん光を用いた低酸素細胞・組織イメージング、光化学、44巻、pp. 86-89、2013.
  12. 吉原利忠、村瀬秋子、飛田成史、りん光性分子プローブによる低酸素細胞イメージング、細胞、45巻、pp. 431-434、2013.
  13. 飛田成史、吉原利忠、穂坂正博、竹内利行、イリジウム錯体のりん光を利用した酸素濃度センサー、 ケミカルエンジニヤリング、55巻、pp. 584-588、2010.
  14. 飛田成史、吉原利忠、穂坂正博、竹内利行、りん光性分子プローブを用いた癌環境イメージング–低酸素の可視化–、Medical Science Digest、35巻、pp. 538-541、2009.
  15. 飛田成史、吉原利忠、小林敦、島田博文、紫外線吸収剤の理論と新規物質開発の考え方、オレオサイエンス, 7巻、pp. 363–370、2007.

著書

  1. 吉原利忠、飛田成史、化学便覧 基礎編 改訂6版（公益財団法人日本化学会　編）、12.5.2 凝縮相での光化学反応、丸善出版
  2. T. Yoshihara, Y. Hirakawa, M. Nangaku, S. Tobita, Quenched-Phosphorescence Detection of Molecular Oxygen: Applications in Life Science (Eds: D. B. Papkovsky, R. I. Dmitriev), Chapter 4 Hydrophilic Ir(III) Complexes for In Vitro and In Vivo Oxygen Imaging, The Royal Society of Chemistry, London
  3. 吉原利忠、ナノテクノロジーが拓く未来の医療（片岡一則　編著）、1-4　りん光を用いた生体内酸素レベル計測、丸善プラネット
  4. 吉原利忠、光と生命の事典（光と生命の事典編集委員会 編）、184 生体光イメージングと分子イメージング、朝倉書店
  5. 吉原利忠、飛田成史、DOJIN BIOSCIENCE SERIES 22 がんの分子イメージング（浦野泰照 編）、第14章 低酸素応答ルミネッセンスに基づくin vivoがんイメージング、化学同仁
  6. 吉原利忠、飛田成史、光老化科学の最前線（前田憲寿 監修）、第25章 分子内エネルギー移動を利用したサンスクリーン、シーエムシー出版
  7. 吉原利忠、光化学の事典（光化学協会光化学の事典編集委員会 編）、6.2.4 光線過敏症、朝倉書店
  8. 吉原利忠、炭素とケイ素の元素科学（松本英之，大谷朝男 監修，海野雅史 編集）、1.8 イリジウム錯体のりん光を利用した細胞・組織イメージング、エレメント・イノベーションプロジェクト
  9. 飛田成史、吉原利忠、穂坂正博、竹内利行、実験医学 増刊（浦野泰照 編集）、第2章4 りん光プローブの設計・開発に基づくin vivo低酸素環境イメージング、羊土社

群馬大学大学院理工学府分子科学部門

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Molecular Photochemistry

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